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Pregnancy: There are no adequate and well-controlled studies in pregnant women.
Remifentanil should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus.
Labour and Delivery: There are insufficient data to recommend remifentanil for use during labour and caesarean section. It is known that remifentanil crosses the placental barrier and fentanyl analogues can cause respiratory depression in the child.
Breast-feeding: It is not known whether remifentanil is excreted in human milk. However, because fentanyl analogues are excreted in human milk and remifentanil-related material was found in rat milk after dosing with remifentanil, nursing mothers should be advised to discontinue breast-feeding for 24 hours following administration of remifentanil.
